Related Experiment Videos
Ultrasound driven synthesis of reversed-phase stationary phases for liquid chromatography using
K B Sentell1, K W Barnes, J G Dorsey
1Department of Chemistry, University of Florida, Gainesville 32611.
Journal of Chromatography
|November 25, 1988
Abstract:
A reproducible new method for synthesizing high density monomeric reversed-phase chromatographic packings based on the use of ultrasonic waves as the driving force for the bonding reaction is presented. The use of ultrasound has two distinct advantages over traditional reflux methods. It provides a reaction driving force that is independent of temperature; in addition, the power of the ultrasonic driving force can be varied using a variable-power ultrasonic probe. The use of a novel acid-acceptor, 4-dimethylaminopyridine, is also recommended in the bonding reaction due to its ease of use and the resulting high bonding densities.