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Anticancer agents and phytotherapy: Interactions that are often unrecognized.

Vanille Laurent1, Justine Saillard1, Margot Thierry1

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Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
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PubMed
Summary

Phytotherapy use in cancer patients poses significant risks of dangerous interactions with anticancer drugs. Many patients do not disclose their use of herbal products to healthcare professionals, highlighting a critical gap in cancer care.

Keywords:
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Area of Science:

  • Oncology
  • Pharmacology
  • Complementary and Alternative Medicine

Background:

  • Phytotherapy is a common complementary medicine used by cancer patients.
  • Consumption of phytotherapy products carries a risk of interaction with anticancer agents.
  • This interaction can potentially alter the efficacy and safety of cancer treatments.

Purpose of the Study:

  • To determine the prevalence of phytotherapy product consumption among cancer patients.
  • To identify and quantify interactions between phytotherapy and anticancer agents.
  • To assess the awareness of phytotherapy use among healthcare professionals.

Main Methods:

  • Prospective study conducted from January 2018 to August 2019.
  • Inclusion of hospitalized hematology patients and outpatients receiving oral anticancer agents.
  • Data collection through pharmaceutical interviews regarding phytotherapy consumption and potential interactions.

Main Results:

  • 40% of hospitalized patients and 17% of outpatients reported phytotherapy use.
  • Significant interaction prevalence: 27% in hospitalized patients and 80% in outpatients.
  • Identified risks include altered drug concentrations, bleeding, hepatotoxicity, and hypokalemia.
  • Healthcare professionals were unaware of phytotherapy use in 44% of hospitalized and 60% of outpatient cases.

Conclusions:

  • The risk of phytotherapy-anticancer agent interactions is substantial and often unrecognized.
  • Healthcare professionals need to be vigilant about phytotherapy use in oncology patients.
  • Tools for detection and training are essential for managing these potential interactions.