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Ageing and longevity genes in cardiovascular diseases
Luca Liberale1,2, Simon Kraler1, Giovanni G Camici1,3,4
1Center for Molecular Cardiology, University of Zürich, Schlieren, Switzerland.
Basic & Clinical Pharmacology & Toxicology
|May 2, 2020
Summary
As societies age, cardiovascular diseases increase due to genetic changes affecting heart and blood vessels. Interventions targeting longevity genes show promise for cardiovascular health.
Area of Science:
- Gerontology and Cardiovascular Medicine
- Molecular Biology and Genetics
Background:
- Western societies face demographic shifts with increased lifespan and decreased fertility, leading to aging populations.
- Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality in aging societies, posing significant societal and economic burdens.
- Aging is linked to genetic network deterioration, causing cellular dysfunction and decline in myocardial and vascular structures and functions.
Purpose of the Study:
- To review genes involved in age-related cardiovascular decline.
- To explore potential strategies for interfering with these age-related genetic processes.
- To highlight interventions promoting cardiovascular health in aging populations.
Main Methods:
- Literature review of genes implicated in senescence and longevity.
- Analysis of cellular processes contributing to cardiovascular aging.
- Evaluation of dietary interventions and compounds affecting sirtuins.
Main Results:
- Identified a compendium of genes influencing cardiovascular aging.
- Dietary interventions like intermittent fasting show protective effects.
- Sirtuin-activating compounds demonstrate promise for cardiovascular health.
Conclusions:
- Aging and longevity genes impact cardiovascular function through inflammation and oxidative stress.
- These genes are promising targets for preventing and treating age-related cardiovascular dysfunction.
- Interventions targeting these pathways offer potential for healthier aging.
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