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Updated: Dec 22, 2025

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Granulomatous and lymphocytic thyroiditis associated with a follicular adenoma
Meora Feinmesser1, David Murray1, Nicholas Colapinto2
1Department of Pathology, St. Michael's Hospital, University of Toronto, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada.
Abstract:
A 44-year-old woman came to medical attention with right thyroid lobe enlargement and weight loss. Thyroid scan and ultrasound demonstrated a nodule in the right thyroid lobe; a right hemithyroidectomy was performed. Histologic examination documented granulomatous and lymphocytic thyroiditis associated with a follicular adenoma. No inflammation was apparent within the adenoma. The parallels between granulomatous thyroiditis and lymphocytic thyroiditis, including presumed viral initiation and deranged immunologic function, suggest that granulomatous thyroiditis may evolve into chronic lymphocytic thyroiditis; this case may be an example of such a transition. It is proposed that thyroid follicular adenomas have different antigenicity, which may account for the conspicuous absence of inflammation within the tumor.
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