Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

14.4K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.4K
Development of Immunocompetence01:22

Development of Immunocompetence

667
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
667
The Thyroid Gland01:23

The Thyroid Gland

6.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.4K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

8.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perceptions of digital pathology among healthcare workers in pathology.

Journal of pathology informatics·2026
Same author

Well-Differentiated Neuroendocrine Tumors of Lung: A Case Series Supporting the IARC/WHO Common Classification of Neuroendocrine Tumor Nomenclature and Grading.

Endocrine pathology·2026
Same author

Parathyroid Carcinoma Mimicking Thyroid Hyalinizing Trabecular Tumor: A Case Report and Review of Atypical Presentations of Parathyroid Carcinoma.

International journal of surgical pathology·2026
Same author

Revisionist history uncovers a simplified molecular-based classification of differentiated thyroid cancer.

The Journal of pathology·2025
Same author

Mimickers of pituitary tumors.

Neuro-oncology advances·2025
Same author

Clinical integration and application of the 2022 WHO pituitary tumor classification.

Neuro-oncology advances·2025
Same journal

Distinct ALK Expression Patterns Are Associated with Canonical and Noncanonical STRN::ALK Transcript Architectures in Oncocytic Thyroid Neoplasms.

Endocrine pathology·2026
Same journal

Neuroendocrine Tumors of the Gallbladder: A Multicenter Case Series and Systematic Literature Review Indicating Predominantly Non-Aggressive Tumor Behavior and a Common Association with Cholesterol Polyps and Cholesterolosis.

Endocrine pathology·2026
Same journal

Genomic Catastrophe Defines the Evolutionary Trajectory of Adrenocortical Carcinoma.

Endocrine pathology·2026
Same journal

Three-Tier Prognostic Stratification of Lung Carcinoids (NET G1-G2-G3) by Multivariable, Data-Driven Integration of Ki-67 and Mitotic Count.

Endocrine pathology·2026
Same journal

Impact of Molecular Testing on Surgical Decision-Making in Indeterminate Thyroid Nodules: A Global Meta-Analysis Across Test Generations.

Endocrine pathology·2026
Same journal

Molecular Profiling of Digestive Grade 3 Neuroendocrine Tumors Reveals a Shared Molecular Framework with Lower-Grade Tumors, Marked Heterogeneity, and Therapeutic Opportunities.

Endocrine pathology·2026
See all related articles

Related Experiment Video

Updated: Dec 22, 2025

Complete Thymectomy in Adult Rats with Non-invasive Endotracheal Intubation
08:35

Complete Thymectomy in Adult Rats with Non-invasive Endotracheal Intubation

Published on: December 29, 2014

17.2K

Thyroid thymoma in childhood.

Corey Weigensberg1, Hubert Daisley1, Sylvia L Asa1

  • 1Department of Pathology, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, Canada.

Endocrine Pathology
|May 3, 2020
PubMed
Summary
This summary is machine-generated.

A rare primary thyroid thymoma was diagnosed in an infant female. This spindle-cell neoplasm, identified via histology and immunohistochemistry, highlights thymoma as a potential cause of pediatric thyroid masses.

Keywords:
Anaplastic CarcinomaEndocrine Pathology VolumeThymomaThyroglobulinThyroid Gland

More Related Videos

Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.4K
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

12.6K

Related Experiment Videos

Last Updated: Dec 22, 2025

Complete Thymectomy in Adult Rats with Non-invasive Endotracheal Intubation
08:35

Complete Thymectomy in Adult Rats with Non-invasive Endotracheal Intubation

Published on: December 29, 2014

17.2K
Isolation and Transplantation of Different Aged Murine Thymic Grafts.
05:47

Isolation and Transplantation of Different Aged Murine Thymic Grafts.

Published on: May 13, 2015

14.4K
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

12.6K

Area of Science:

  • Pediatric Pathology
  • Endocrine Neoplasms
  • Thyroid Tumors

Background:

  • Thyroid masses in infants and children are uncommon.
  • Differential diagnosis of pediatric thyroid nodules includes various neoplastic and non-neoplastic conditions.
  • Primary thymoma of the thyroid is an exceptionally rare entity.

Purpose of the Study:

  • To report a case of primary thyroid thymoma in a pediatric patient.
  • To describe the histological, immunohistochemical, and ultrastructural features of this rare tumor.
  • To emphasize the importance of considering thymoma in the differential diagnosis of pediatric thyroid masses.

Main Methods:

  • Histopathological examination of a surgically resected thyroid nodule.
  • Immunohistochemical staining for low-molecular-weight keratins, S-100 protein, leukocyte common antigen, calcitonin, and thyroglobulin.
  • Electron microscopy to evaluate cellular ultrastructure.

Main Results:

  • The tumor presented as a lobulated spindle-cell neoplasm with focal epithelioid differentiation.
  • Diffuse positivity for low-molecular-weight keratins was observed.
  • Scattered cells stained positive for S-100 protein and leukocyte common antigen, while negative for calcitonin and thyroglobulin.
  • Electron microscopy revealed intracytoplasmic tonofilaments and desmosomes, consistent with epithelial differentiation.

Conclusions:

  • The findings support the diagnosis of primary thyroid thymoma based on integrated clinicopathological, immunohistochemical, and ultrastructural data.
  • Primary thyroid thymoma, though rare, should be included in the differential diagnosis of thyroid masses in infants and children.
  • This case expands the understanding of thymoma presentation in pediatric patients.