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Updated: Dec 22, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Silent mixed growth hormone cell-prolactin cell pituitary adenoma
Shigeru Furuhata1, Toru Kameya2, Mitsuhiro Otani1
1Department of Neurosurgery, Keio University School of Medicine, Tokyo.
Abstract:
The case of a 51 -year-old man with recurrent nonfunctioning pituitary adenoma is presented. Despite clinically and endocrinologically normal pituitary function in regard to growth hormone and prolactin, many growth hormone- and prolactin-positive cells were immunohis-tochemically detected in adenoma tissue. Furthermore, a quite rare tumor of silent mixed growth hormone cell-prolactin cell pituitary adenoma was confirmed by the double-labeling immunoelectron-microscopical study.
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