Effect of Nectaroscordum koelzi Methanolic Extract on Acute and Chronic Inflammation in Male Mice
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Mojtaba Khaksarian1, Hormoz Mahmoudvand2, Maryam Alipour1
1Razi Herbal Medicines Research Center & Department of Physiology, Lorestan University of Medical Sciences, Khorramabad, Iran.
Introduction:
The present study deals with the effect of Nectaroscordum koelzi fruit extract on acute and chronic inflammation.
Methods:
A total of 84 NMRI mice were used in this study. The effect of the extract on acute inflammation was analyzed by increasing vascular permeability via acetic acid and xylene induced ear edema among mice. The extract was evaluated in terms of effects on chronic inflammation by means of the cotton pellet test among mice. For the assessment of inflammation degree, the mice paw edema volume was measured by the plethysmometric test.
Results:
The findings showed that the extract was effective on acute inflammation induced by acetic acid in mice. In the xylene ear edema, N. koelzi extract indicated a significant activity in mice. In the cotton pellet method, the methanol extract produced a significant reduction in comparison with the control and dexamethasone. Mice paw edema volume decreased with the extract.
Conclusion:
In general, the data from the experiments indicated that the methanol extract of N. koelzi has an anti-inflammatory effect on acute and chronic inflammation. However, the exact contributing mechanisms have not been investigated for the pharmacological effects.
Insights
Nectaroscordum koelzi fruit extract demonstrates significant anti-inflammatory effects against both acute and chronic inflammation in mice. This natural compound effectively reduced swelling and inflammation markers in various experimental models.
Area of Science:
- Pharmacology
- Natural Product Chemistry
- Inflammation Research
Background:
- Inflammation is a complex biological response implicated in numerous diseases.
- Natural products are a rich source of potential therapeutic agents for inflammatory conditions.
Purpose of the Study:
- To investigate the anti-inflammatory potential of Nectaroscordum koelzi fruit extract.
- To evaluate the extract's efficacy in models of acute and chronic inflammation.
Main Methods:
- Acute inflammation was assessed using acetic acid-induced vascular permeability and xylene-induced ear edema in mice.
- Chronic inflammation was evaluated using the cotton pellet method in mice.
- Paw edema volume was measured using a plethysmometric test.
Main Results:
- Nectaroscordum koelzi extract showed significant effectiveness in reducing acute inflammation induced by acetic acid.
- The extract demonstrated significant anti-inflammatory activity in the xylene-induced ear edema model.
- A significant reduction in chronic inflammation was observed with the methanol extract in the cotton pellet test, comparable to dexamethasone.
Conclusions:
- The methanol extract of Nectaroscordum koelzi possesses notable anti-inflammatory properties for both acute and chronic inflammation.
- Further research is warranted to elucidate the specific pharmacological mechanisms underlying these anti-inflammatory effects.
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