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Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes

Stephan C Jahn1, Lauren A Gay1, Claire J Weaver1

  • 1Departments of Medicinal Chemistry (S.C.J., C.J.W., M.O.J.), Pharmacotherapy and Translational Research (T.Y.L.), Medicine (P.W.S.), Biochemistry and Molecular Biology (P.W.S.), and Molecular Genetics and Microbiology (L.A.G., R.R.), University of Florida, Gainesville, Florida.

Drug Metabolism and Disposition: the Biological Fate of Chemicals
|May 3, 2020
PubMed
Summary

MicroRNAs (miRNAs) regulate the expression of glutathione transferase zeta 1 (GSTZ1) protein in the liver. Specifically, miR-376c-3p inhibits GSTZ1 production, impacting drug metabolism and offering insights for dichloroacetate dosing.

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