Related Experiment Video

Updated: Dec 22, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.8K

The Matching Status Between Donor and Recipient Hepatitis B Seroepidemiology Makes a Difference in Liver

Di Lu1,2, Fan Yang1,2, Jianyong Zhuo1,2

  • 1Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Clinical and Translational Gastroenterology
|May 3, 2020
PubMed

Insights

Antibody to hepatitis B core antigen (HBcAb) in liver transplant recipients indicates a higher risk of hepatocellular carcinoma (HCC) recurrence. A new nomogram incorporating HBcAb and donor HBsAg status aids in predicting recurrence, improving post-transplant outcomes.

Area of Science:

  • Hepatology
  • Transplant Surgery
  • Oncology

Background:

  • Hepatocellular carcinoma (HCC) is a leading cause of liver cancer.
  • Liver transplantation is a curative option for select HCC patients.
  • Prognostic factors for post-transplant HCC recurrence require further elucidation.

Purpose of the Study:

  • To evaluate the prognostic value of antibody to hepatitis B core antigen (HBcAb) and other hepatitis B seroepidemiological markers in HCC transplantation.
  • To develop a predictive model for post-transplant HCC recurrence risk.

Main Methods:

  • Analysis of a national liver transplant registry data.
  • Retrospective study of HCC patients undergoing liver transplantation.
  • Development and validation of a risk-predicting nomogram using training and validation cohorts.

Main Results:

  • Positive HBcAb in recipients correlated with increased HCC recurrence across various etiologies.
  • Donor hepatitis B surface antigen (HbsAg) positivity also associated with recurrence in HBV-related HCC.
  • A nomogram integrating recipient HBcAb, donor HBsAg, AFP, and Milan criteria demonstrated strong prognostic capacity.

Conclusions:

  • Recipient HBcAb is a significant predictor of post-transplant HCC recurrence.
  • The developed nomogram effectively predicts recurrence risk, potentially expanding eligibility for liver transplantation in HCC patients.
Abstract

More Related Videos

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

4.4K
Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

3.3K

Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
802
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
730
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
245