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Activity of protein kinase C in erythrocytes in primary hypertension

G M Kravtsov1, N O Dulin, Y V Postnov

  • 1Central Research Laboratory, Ministry of Public Health, Moscow, USSR.

Journal of Hypertension
|November 1, 1988
PubMed

The activity of protein kinase C and A was studied in the erythrocytes of patients with essential hypertension (EH) and in spontaneously hypertensive rats (SHR, Okamoto-Aoki strain). Protein kinase C activity was also studied in the erythrocytes of patients with hypertension of renal origin. Protein kinase C activity in the lysate of erythrocytes of patients with EH and in SHR was found to be increased 1.6-2.0-fold as compared to that in normotensive controls. No notable differences in protein kinase A activity were observed between hypertensive and normotensive groups. In erythrocytes of patients with renal hypertension, no notable changes in protein kinase C activity were revealed.

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