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Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Traditional serrated adenomas (TSA) and the company they keep: TSA presence predicts advanced neoplasm states
Erica Duh1, Piotr Sowa2, Mary B Roberts3
1Department of Internal Medicine, University of California Irvine Medical Center, 101 The City Drive, City Tower, Suite 400, Orange, CA, 92806, USA. eduh1@uci.edu.
Background:
The association of TSAs with metachronous neoplasms is well established and suggests that TSAs would also have an association with synchronous neoplasms.
Methods:
We compared odds ratios and rates of synchronous neoplasms found in colonoscopies with and without TSAs.
Results:
There was a mean of 2.44 neoplasms among TSA cases in comparison with 1.72 in non-TSA cases. The odds ratio for advanced neoplasia was highest among cases with one or more TSAs relative to cases with one or more HPs (7.54 [CI, 4.23-13.44]) when compared with adenomas (1.95 [CI, 1.75-2.17]) and SSPs (2.98 [CI, 2.54-3.5]).
Conclusions:
In this study population, there is a 7-fold higher risk of synchronous advanced neoplasms among cases with one or more TSAs.
