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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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Interleukin-17: A Social Cytokine.
Casper C Hoogenraad1, Lorena Riol-Blanco2
1Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA.
Cell
|May 4, 2020
Summary
Inflammation-induced fever can improve autism spectrum disorder (ASD) behaviors. Researchers found that interleukin-17 (IL-17) produced during inflammation enhances social behavior in mouse models of neurodevelopmental disorders.
Area of Science:
- Neuroscience
- Immunology
- Developmental Biology
Background:
- Some children with autism spectrum disorder (ASD) exhibit behavioral improvements during inflammatory responses with fever.
- The underlying biological mechanisms for these beneficial effects remain largely unknown.
- Understanding these mechanisms is crucial for developing targeted therapies.
Purpose of the Study:
- To investigate the role of inflammation-induced cytokines in modulating social behavior in neurodevelopmental disorders.
- To elucidate the specific mechanisms by which inflammation impacts behavior in models of ASD.
- To identify potential therapeutic targets for behavioral interventions.
Main Methods:
- Utilized mouse models of neurodevelopmental disorders.
- Induced controlled inflammatory responses and monitored associated behavioral changes.
- Quantified the production of specific cytokines, including interleukin-17 (IL-17).
- Assessed social interaction behaviors in the animal models.
Main Results:
- Demonstrated that inflammation, particularly when accompanied by fever, can positively influence social behavior.
- Identified interleukin-17 (IL-17) as a key mediator in this process.
- Showcased that IL-17 production during inflammation promotes social behavior in the studied mouse models.
Conclusions:
- Interleukin-17 (IL-17) plays a significant role in mediating the beneficial effects of inflammation on social behavior.
- These findings offer novel insights into the complex interplay between the immune system and neurodevelopment.
- Suggests IL-17 as a potential therapeutic target for improving social deficits in neurodevelopmental disorders.
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