Effect of green cardamom on lipoproteins, glycemic control and anthropometric parameters: A meta-analysis of
Omid Asbaghi1, Elham Eslampour1, Željko Reiner2
1Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Insights
Green cardamom supplementation significantly reduced triglyceride levels. However, it did not impact other lipid profiles, glucose levels, or body weight, though it increased BMI in some studies.
Area of Science:
- Nutritional Science
- Metabolic Health
- Evidence-Based Medicine
Background:
- Cardamom is a spice used in traditional medicine.
- Its effects on metabolic markers are not fully understood.
- Systematic reviews are needed to consolidate evidence.
Purpose of the Study:
- To systematically review and meta-analyze randomized controlled trials (RCTs) on green cardamom's effects.
- To evaluate impacts on lipoproteins, glycemic control, and anthropometric parameters.
- To compare outcomes in healthy individuals and those with diseases.
Main Methods:
- Systematic search of EMBASE, Scopus, PubMed, Cochrane Library, Web of Science.
- Inclusion of RCTs with data on serum lipoproteins, glycemic control, and anthropometric parameters.
- Random-effects model used for data pooling; heterogeneity assessed with Cochrane's Q and I² statistics.
Main Results:
- Seven trials were included in the meta-analysis.
- Green cardamom significantly reduced triglyceride levels compared to controls.
- No significant effects observed on total cholesterol, LDL-C, HDL-C, fasting plasma glucose, or body weight.
Conclusions:
- Green cardamom intake significantly lowers triglyceride levels.
- This reduction may indirectly improve metabolic disorder symptoms.
- Further research on cardamom's role in metabolic health is warranted.
Introduction:
The aim of this systematic review and meta-analysis was to summarize all the existing randomized controlled trials (RCTs) evidence and to evaluate the effects of green cardamom on lipoproteins, glycemic control and anthropometric parameters in healthy and/or with disease types compared with the control.
Method:
Two independent authors systematically searched online databases including EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until 30th July 2019. RCTs complying with the following criteria were included in this meta-analysis: human trials with either cross-over design or parallel design, trials with data on the effects of green cardamom on serum lipoproteins and glycemic control and anthropometric parameters with standard deviation and related 95% confidence interval for the both intervention and placebo groups. The heterogeneity among the included studies was assessed using Cochrane's Q test and I-square (I2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.
Result:
Seven trials were included in this meta-analysis. Triglycerides were significantly reduced after cardamom supplementation when compared with the control group. Cardamom intake from 3 small studies resulted in a significant increase in BMI when compared with the control group. However, cardamom supplementation did not have any significant effect on total cholesterol, LDL-cholesterol, HDL-cholesterol, fasting plasma glucose and body weight when compared with the control group.
Conclusion:
This meta-analysis demonstrated that green cardamom intake significantly reduced triglycerides levels which may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders.
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