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Updated: Dec 22, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Arterial Stiffness Assessed by Oscillometric Method in Kidney Transplant, Predialysis, and Dialysis Patients

Piotr Olczyk1, Artur Małyszczak2, Tomasz Gołębiowski1

  • 1Department of Nephrology and Transplantation Medicine, Wrocław Medical University, Wrocław, Poland.

Transplantation Proceedings
|May 4, 2020
PubMed

Insights

Vascular stiffness, a key cardiovascular risk factor in chronic kidney disease (CKD), is highest in hemodialysis patients. Kidney transplant recipients and predialysis CKD patients have similar large artery stiffness, but transplant recipients show greater small artery stiffness.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Chronic kidney disease (CKD) significantly increases cardiovascular disease (CV) risk.
  • Vascular stiffness, measured by pulse wave velocity (PWV) and augmentation index (AIx@75), is a critical nontraditional CV risk factor in renal patients.

Purpose of the Study:

  • To compare vascular stiffness among kidney transplant (KTx) recipients, patients undergoing maintenance dialysis (HD), and those in the predialysis CKD stages (G3-4).

Main Methods:

  • A cross-sectional study involving 140 patients: 52 with CKD G3-4, 37 on HD, and 51 KTx recipients.
  • Vascular stiffness was assessed using oscillometric measurement of PWV and AIx@75 via the Mobil-O-Graph device.

Main Results:

  • Hemodialysis (HD) patients exhibited significantly higher PWV (9.4 m/s) compared to KTx (8.4 m/s) and CKD G3-4 (7.9 m/s) patients.
  • AIx@75 was significantly lower in CKD G3-4 patients (17.8) compared to HD (27.1) and KTx (25.6) groups, which were comparable.

Conclusions:

  • Hemodialysis patients present the highest cardiovascular risk due to elevated vascular stiffness (PWV).
  • While large artery stiffness (PWV) is similar between KTx and CKD G3-4 patients, KTx recipients demonstrate increased small artery stiffness (AIx@75).
Abstract

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