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Anti-inflammatory principles from Lindera aggregata.

Ping-Chung Kuo1, Yi-Hung Wu2, Hsin-Yi Hung1

  • 1School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.

Bioorganic & Medicinal Chemistry Letters
|May 4, 2020
PubMed
Summary

New compounds from Lindera aggregata, including novel sesquiterpenes, were identified. Some compounds, like linderaggredin C, showed significant anti-inflammatory effects by inhibiting superoxide anion generation in neutrophils.

Keywords:
AlkaloidAnti-inflammatoryBenzenoid glycosideElastase releaseSesquiterpeneSuperoxide anion generation

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Pharmacology

Background:

  • Lindera aggregata is a plant source of various bioactive compounds.
  • Sesquiterpenes, alkaloids, and glycosides are classes of natural products with diverse biological activities.
  • Inflammation is a complex biological response implicated in numerous diseases.

Purpose of the Study:

  • To isolate and characterize new chemical constituents from Lindera aggregata.
  • To elucidate the structures of these novel compounds using spectroscopic methods.
  • To evaluate the anti-inflammatory potential of the isolated compounds.

Main Methods:

  • Extraction and isolation of compounds from Lindera aggregata.
  • Structure elucidation using advanced spectrometric techniques (e.g., NMR, MS).
  • In vitro bioactivity assays to assess anti-inflammatory properties, specifically superoxide anion generation inhibition in human neutrophils.

Main Results:

  • Four new sesquiterpenes (1-4), one new alkaloid (5), and one new benzenoid glycoside (6) were identified.
  • Compounds 3 and 4 possess unique, unprecedented carbon skeletons.
  • Linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine demonstrated significant inhibition of superoxide anion generation with IC50 values of 7.45 ± 0.74 μM, 8.36 ± 0.11 μM, and 5.81 ± 0.59 μM, respectively.

Conclusions:

  • Lindera aggregata is a rich source of structurally novel natural products.
  • The identified compounds, particularly linderaggredin C, exhibit promising anti-inflammatory activity.
  • These findings suggest potential therapeutic applications for Lindera aggregata constituents in managing inflammatory conditions.