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1H-nmr analysis of herbimycins and dihydro-herbimycins
L Z Lin1, G Blaskó, G A Cordell
1Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago 60612.
Journal of Natural Products
|November 1, 1988
Abstract:
Herbimycin A [1] and herbimycin C [3] and their dihydro-derivatives 5 and 6, respectively, have been obtained from the cell broth of Streptomyces hygroscopicus, and the assignment of their 1H-nmr has been completed. Strong cytotoxic activity of antibiotics 1, 3, 5, and 6 against the P-388 and KB lymphocytic leukemia test systems has been demonstrated.