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Association of Systemic Hypertension With Primary Open-angle Glaucoma: A Population-based Case-Control Study
Tung-Mei Kuang1, Sudha Xirasagar2, Yi-Wei Kao3
1Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan; Research Center of Sleep Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
American Journal of Ophthalmology
|May 4, 2020
Summary
Systemic hypertension (high blood pressure) is linked to primary open-angle glaucoma (POAG). Regular eye exams are recommended for hypertension patients, and blood pressure monitoring for glaucoma patients.
Area of Science:
- Ophthalmology
- Cardiology
- Public Health
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
- Systemic hypertension (HTN) is a prevalent condition with known cardiovascular implications.
- The relationship between HTN and POAG requires further investigation using large-scale population data.
Purpose of the Study:
- To investigate the association between systemic hypertension (HTN) and primary open-angle glaucoma (POAG).
- Utilize Taiwan's nationwide health insurance claims data for a comprehensive analysis.
Main Methods:
- A case-control study design was employed.
- Data included 112,929 newly diagnosed POAG patients (cases) and 449,840 propensity score-matched controls.
- Multiple logistic regression analysis was performed to assess the odds of prior HTN.
Main Results:
- Over half (52.81%) of the total 562,300 study participants had a history of HTN.
- POAG cases had a significantly higher prevalence of prior HTN (56.49%) compared to controls (51.90%).
- POAG was significantly associated with prior HTN (OR 1.31, 95% CI 1.29-1.33) after multivariable adjustment.
Conclusions:
- Pre-existing systemic hypertension is associated with primary open-angle glaucoma.
- Internal medicine and family medicine physicians should refer patients with hypertension for regular ophthalmological evaluations.
- Ophthalmologists should advise glaucoma patients to monitor their blood pressure regularly.
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