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Xylan-based hydrogels for potential skin care application.

Gen-Que Fu1, Sheng-Chun Zhang1, Ge-Gu Chen1

  • 1Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, Beijing 100083, China.

International Journal of Biological Macromolecules
|May 4, 2020
PubMed
Summary
This summary is machine-generated.

This study presents a novel natural biomaterial for skincare. The dialdehyde xylan (DAX) hydrogel, incorporating gelatin and nicotinamide (NCA), shows excellent skin care potential, including antibacterial properties and smooth NCA release.

Keywords:
Dialdehyde xylanHydrogelSkin care

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Area of Science:

  • Biomaterials Science
  • Dermatology
  • Polymer Chemistry

Background:

  • Growing demand for natural compounds in skincare biomaterials.
  • Need for advanced hydrogel formulations with enhanced functionality.

Purpose of the Study:

  • To fabricate a novel dialdehyde xylan (DAX) crosslinked hydrogel for skincare applications.
  • To evaluate the hydrogel's texture, antibacterial properties, and nicotinamide (NCA) release profile.
  • To assess the cytocompatibility of the developed hydrogel material.

Main Methods:

  • Fabrication of a hydrogel using dialdehyde xylan (DAX) as a crosslinker for gelatin (G).
  • Incorporation of glycerol (Gly) and nicotinamide (NCA) to enhance properties.
  • In vitro release studies for NCA.
  • Antibacterial assays against Yeast, Bacillus subtilis, and Staphylococcus aureus.
  • Cytocompatibility testing.

Main Results:

  • Successful fabrication of a DAX-crosslinked gelatin hydrogel.
  • Demonstrated smooth in vitro release of NCA from the hydrogel matrix.
  • Exhibited significant antibacterial activity, with efficacy order: Yeast > Bacillus subtilis > Staphylococcus aureus.
  • Confirmed excellent cytocompatibility, indicating cell viability.

Conclusions:

  • The developed xylan-based hydrogel is a promising natural biomaterial for skincare.
  • Its ability to load and release NCA, coupled with antibacterial and cytocompatible properties, makes it suitable for skincare formulations.
  • This hydrogel offers a potential matrix for advanced topical treatments.