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Maresin-1 resolution with RORα and LGR6.

Dong-Soon Im1

  • 1Laboratory of Pharmacology, College of Pharmacy, Department of Life Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.

Progress in Lipid Research
|May 4, 2020
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Summary

Maresin-1, a lipid mediator, targets two receptors: RORα and LGR6. Understanding these interactions is key to exploring maresin-1

Keywords:
G protein-coupled receptorInflammationLGR6Maresin-1Nuclear receptorRORαResolution

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Area of Science:

  • Lipid mediator pharmacology
  • Receptor pharmacology
  • Inflammation resolution biology

Background:

  • Maresin-1 is a pro-resolving lipid mediator with significant pharmacological interest.
  • Two distinct receptor targets for maresin-1 have been identified: RORα and LGR6.
  • RORα is a nuclear receptor, while LGR6 is a plasma membrane GPCR.

Purpose of the Study:

  • To review the pharmacology of maresin-1's newly identified receptor targets.
  • To elucidate the roles of RORα and LGR6 in maresin-1's pro-resolving functions.
  • To explore maresin-1's impact on inflammation resolution, host defense, tissue homeostasis, and wound healing.

Main Methods:

  • Pharmacological review of maresin-1 and its identified receptors.
  • Analysis of intracellular signaling pathways involved in maresin-1 resolution.
  • Literature synthesis on the functions of RORα and LGR6 in biological processes.

Main Results:

  • Maresin-1 interacts with both retinoic acid-related orphan receptor α (RORα) and leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6).
  • The distinct cellular localizations (nuclear vs. plasma membrane) of RORα and LGR6 suggest diverse signaling mechanisms.
  • The identification of these dual targets opens avenues for understanding maresin-1's multifaceted roles.

Conclusions:

  • Understanding maresin-1's interaction with RORα and LGR6 is crucial for its therapeutic potential.
  • Further research into the specific functions mediated by each receptor will clarify maresin-1's role in health and disease.
  • This review highlights the expanding pharmacological landscape of maresin-1 and its implications for resolution biology.