Amphetamine/Dextroamphetamine Salts for Delayed Orgasm and Anorgasmia in Men: A Pilot Study

Area of Science:

• Urology
• Sexual Medicine
• Pharmacology

Background:

• Delayed orgasm/anorgasmia (DO/AO) is a distressing sexual dysfunction.
• Limited effective pharmacological treatments exist for DO/AO.
• Amphetamine/dextroamphetamine salts (AMP) have been anecdotally considered for sexual dysfunction.

Purpose of the Study:

• To evaluate the efficacy and safety of amphetamine/dextroamphetamine salts (AMP) for treating delayed orgasm/anorgasmia (DO/AO).
• To assess changes in orgasmic latency time (OLT) and patient satisfaction.
• To identify predictors of treatment success.

Main Methods:

• A retrospective study of 17 male patients diagnosed with DO/AO treated with AMP.
• Collected baseline characteristics, orgasmic latency time (OLT), and used validated questionnaires.
• Analyzed OLT changes, adverse effects, and patient satisfaction, comparing responders and non-responders.

Main Results:

• 35.3% of patients experienced reduced OLT or increased orgasm frequency.
• Mean OLT decreased by 72.3% in responders with DO.
• Minimal side effects like insomnia and jitters were reported; older non-responders were noted.

Conclusions:

• Amphetamine/dextroamphetamine salts (AMP) demonstrate potential as a treatment for DO/AO.
• Over a third of patients showed measurable improvements in OLT or orgasm frequency.
• Larger prospective studies are warranted to validate AMP's role in treating sexual dysfunction.