Related Experiment Video

Updated: Dec 22, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.1K

Deregulated PTEN/PI3K/AKT/mTOR signaling in prostate cancer: Still a potential druggable target?

Luca Braglia1, Manuela Zavatti2, Marco Vinceti2

  • 1Department of Biomedical, Metabolic, and Neurological Sciences, University of Modena and Reggio Emilia, 41124 Modena, MO, Italy; Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, BO, Italy.

Biochimica Et Biophysica Acta. Molecular Cell Research
|May 4, 2020
PubMed

Insights

Prostate cancer often relapses after treatment, progressing to castration-resistant disease. Targeting the phosphoinositide 3-kinase (PI3K) pathway offers a potential strategy to improve treatment efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Prostate cancer prognosis is good after initial treatment, but one-third of patients relapse.
  • Relapse often leads to castration-resistant prostate cancer, for which treatments are limited.
  • The phosphoinositide 3-kinase (PI3K) pathway is frequently dysregulated in prostate cancer, contributing to progression and treatment resistance.

Purpose of the Study:

  • To summarize the biological functions of key PI3K pathway components.
  • To review PI3K pathway deregulation in prostate cancer.
  • To summarize preclinical and clinical studies of PI3K signaling inhibitors.

Main Methods:

  • Literature review of biological functions of PI3K pathway components.
  • Analysis of genetic, epigenetic, and post-translational modifications in prostate cancer.
  • Summary of preclinical and clinical studies involving PI3K inhibitors.

Main Results:

  • PI3K pathway dysregulation is common in prostate cancer onset, progression, and resistance to androgen deprivation therapy.
  • Studies on PI3K signaling inhibitors show varied outcomes, with failures sometimes independent of genomic alterations.
  • Understanding PI3K pathway mechanisms is crucial for developing effective prostate cancer therapies.

Conclusions:

  • Targeting the PI3K pathway is a promising avenue for overcoming resistance in prostate cancer.
  • Further research is needed to understand the complex mechanisms of PI3K pathway deregulation and inhibitor response.
  • Developing novel therapeutic strategies that enhance current treatments is essential for improving patient outcomes.
Keywords:
PIK3CA mutationPTEN deletionPTEN/PI3K/AKT/mTOR signalingProstate cancerResistanceTargeted therapy

More Related Videos

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer06:51

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer

Published on: July 21, 2018

18.4K
An Orthotopic Murine Model of Human Prostate Cancer Metastasis06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.7K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
11.5K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.1K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.1K