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Meperidine and normeperidine distribution in the rhesus monkey
J C Morrison1, J N Martin, R J Christie
1Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505.
Summary
Meperidine and its metabolite normeperidine cross the placenta in rhesus monkeys. Normeperidine concentrates more in fetal tissues like the brain, potentially explaining its toxicity.
Area of Science:
- Pharmacology
- Toxicology
- Reproductive Biology
Background:
- Meperidine and normeperidine cross the placenta.
- Limited data exists on primate fetal tissue deposition of these compounds.
Purpose of the Study:
- To investigate the tissue distribution of meperidine and normeperidine in newborn rhesus monkeys.
- To understand the implications for fetal exposure and potential toxicity.
Main Methods:
- Four pregnant rhesus monkeys received an IV mixture of meperidine and normeperidine before cesarean delivery.
- Infant tissues and serum were analyzed for compound concentrations using gas-liquid chromatography and mass spectroscopy (GLC-MS).
Main Results:
- Infant serum showed a 3:1 ratio of meperidine to normeperidine.
- Liver, gallbladder, and brain tissues exhibited higher concentrations of normeperidine compared to meperidine.
- Muscle and kidney tissues showed equal concentrations of both compounds.
Conclusions:
- Normeperidine is rapidly transferred to fetal tissues, with higher deposition in specific organs like the brain.
- Increased brain distribution of normeperidine may contribute to its neurotoxic effects in neonates exposed to meperidine.