MOG-antibody-associated hypertrophic pachymeningitis
Athanasios Papathanasiou1, Jing-Ming Yeo1, Miles Humberstone2
1Department of Neurology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK.
Background:
The clinical spectrum of myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease is expanding.
Objective:
To describe an unusual case of MOG-antibody-associated hypertrophic pachymeningitis (HP).
Methods:
Case study.
Results:
A 57-year-old female presented with a generalised seizure on a background of 3 months history of progressive cognitive decline and behavioural changes. Brain Magnetic Resonance Imaging (MRI) revealed widespread pachymeningeal enhancement and hyperintense signal in both hippocampi. Cerebrospinal Fluid (CSF) examination was normal. The patient was found positive for MOG-antibody. She clinically improved with steroids and the MRI abnormalities completely resolved.
Conclusions:
Clinicians might consider testing for MOG-antibody in cases with HP.
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