[Short peptides: regulation of skin function during aging.]
V K Khavinson1,2, N S Linkova1,3, A S Diatlova1
1Saint-Petersburg Institute of Bioregulation and Gerontology, 3 pr. Dinamo, St. Petersburg 197110, Russian Federation,
Advances in Gerontology = Uspekhi Gerontologii
|May 4, 2020
Summary
Short peptides support skin aging by penetrating the epidermis to influence dermal cells. These molecules, including polyfunctional peptides, offer antioxidant and anti-aging benefits, promoting healthier skin function.
Area of Science:
- Molecular gerontology
- Dermatology
- Biochemistry
Background:
- Short peptides can penetrate the stratum corneum to affect dermal cells.
- Peptides are integral to cellular metabolism and possess geroprotective properties.
- Skin aging is a complex process influenced by cellular function and extracellular matrix integrity.
Purpose of the Study:
- To review the primary types of peptides used for normalizing skin fibroblast function.
- To highlight the geroprotective and functional benefits of various peptide classes.
- To emphasize the role of polyfunctional peptides in skin aging.
Main Methods:
- Literature review of scientific articles on peptide applications in skin aging.
- Analysis of peptide mechanisms of action on skin cells and extracellular matrix.
- Categorization of peptides based on their functional properties and applications.
Main Results:
- Identified key peptide categories: matrikines, carnosine, collagen peptides, cytokine and growth factor analogs, defensins, immunoprotective peptides, and polyfunctional peptides.
- Polyfunctional peptides (AcSDKP, KED, AEDG, AED) demonstrate geroprotective effects, inhibiting apoptosis and stimulating proliferation.
- These peptides enhance fibroblast activity, normalize matrix hemostasis, act as antioxidants and immunoprotectors, and improve dermal microcirculation.
Conclusions:
- Peptide-based regulation of skin function during aging is a rapidly advancing field in molecular gerontology.
- Polyfunctional peptides offer significant potential for anti-aging skincare due to their multifaceted benefits.
- Further research into peptide mechanisms can lead to novel therapeutic strategies for skin rejuvenation.
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