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[The information content and predictive value of cardiac markers in myocardial infarction in the elderly.]

N M Agarkov1, M Y Markelov2, E A Markelova2

  • 1South-Western State University, 94 str. 50 let Oktyabrya, Kursk 305040, Russian Federation,

Advances in Gerontology = Uspekhi Gerontologii
|May 4, 2020
PubMed

Insights

Cardiac markers like Troponin T are crucial for diagnosing myocardial infarction in elderly patients. These markers help identify high-risk individuals, improving patient outcomes and mortality rates in older populations.

Area of Science:

  • Cardiology
  • Geriatrics
  • Biochemistry

Background:

  • Myocardial infarction is a leading cause of death in elderly individuals.
  • Accurate prognostic markers are essential for managing cardiac events in older adults.

Purpose of the Study:

  • To evaluate the prognostic significance and diagnostic value of cardiac blood markers in elderly patients with myocardial infarction.
  • To compare the informativeness of various cardiac markers between older (65-75 years) and younger (50-60 years) adult groups.

Main Methods:

  • Cardiac markers were analyzed in 107 elderly (65-75 years) and 83 younger (50-60 years) myocardial infarction patients.
  • Methods included immunochromatography, bioluminescence, and electrophoresis on cellulose acetate.
  • Informativeness and prognostic coefficients were calculated, with a control group of 95 elderly individuals without myocardial infarction.

Main Results:

  • Troponin T, brain natriuretic peptide, glucose-6-phosphate dehydrogenase, and lactate dehydrogenase-1 demonstrated the highest informative and prognostic value in elderly patients.
  • These specific markers were identified as key indicators for assessing risk in older adults post-myocardial infarction.

Conclusions:

  • Specific cardiac markers, including Troponin T and brain natriuretic peptide, are highly informative for prognostication in elderly patients with myocardial infarction.
  • Utilizing these markers can enhance the diagnosis and identification of high-risk individuals, thereby improving clinical management strategies.

Keywords:
cardiomarkersdiagnosis of myocardial infarctionmyocardial infarctionprognosis of myocardial infarction

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