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Related Concept Videos

Drug Distribution: Tissue Binding01:21

Drug Distribution: Tissue Binding

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Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
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Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

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Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
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Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
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Drug Elimination by Renal Route: Tubular Reabsorption01:22

Drug Elimination by Renal Route: Tubular Reabsorption

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During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. However, the majority of drugs are either weak acids or weak bases, and their ionization level is dependent on pH. By altering the pH of urine, the...
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Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

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The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
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Tissue-Drug Binding: Localization of Drugs and its Significance01:24

Tissue-Drug Binding: Localization of Drugs and its Significance

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Body tissues, comprising approximately 40% of the body weight, are crucial in drug distribution and localization. These tissues can serve as drug storage sites, competing with plasma binding sites for drug molecules.
Drugs can bind to different tissue components, enhancing their distribution and localization. The factors influencing drug localization in tissues include the drug's lipophilicity, structural characteristics, tissue perfusion rate, and pH differences. These factors determine...
337

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Related Experiment Video

Updated: Dec 22, 2025

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

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Chapter 11.6 Clays and Clay Minerals as Drugs.

M T Droy-Lefaix1, F Tateo2

  • 1Beaufour-IPSEN, F-75016 Paris, France.

Developments in Clay Science
|May 5, 2020
PubMed
Summary

Clay minerals offer therapeutic benefits for gut disorders by adsorbing harmful substances and strengthening the gut lining. These natural materials enhance the mucus barrier, protecting the gastrointestinal mucosa from damage.

Area of Science:

  • Geology
  • Pharmacology
  • Gastroenterology

Background:

  • The gastrointestinal mucosa is protected by a dynamic mucus gel layer.
  • This mucus layer acts as a crucial physical and chemical barrier against gut aggressors.
  • Environmental factors and pathogens can compromise the integrity of this protective mucus layer.

Purpose of the Study:

  • To explore the therapeutic applications of clay materials in treating gastrointestinal disorders.
  • To elucidate the mechanisms by which clay minerals exert beneficial effects on the gastrointestinal mucosa.

Main Methods:

  • Review of existing literature on clay mineral applications in medicine.
  • Analysis of the physicochemical properties of clay minerals relevant to biological interactions.

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  • Examination of the interaction between clay minerals and gastrointestinal mucus.

    • Main Results:

    • Clay minerals demonstrate efficacy against various gut aggressors and associated disorders.
    • Two primary mechanisms of action identified: adsorption of toxins and modification of mucus properties.
    • Clay minerals enhance the thickness and rheological characteristics of the adherent mucus gel.

    Conclusions:

    • Clay minerals serve as effective therapeutic agents for gastrointestinal conditions.
    • Their dual action of adsorption and mucus reinforcement bolsters the gut's natural defenses.
    • Further research into clay-based pharmaceuticals for gut health is warranted.