Lead Anti-Obesity Compounds from Nature
Vinesh Dahiya1, Neeru Vasudeva1, Sunil Sharma1
1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, India.
Background:
Obesity has become a global issue, leading to increased risk of metabolic syndrome, which encompasses diabetes, cardiovascular disease, stroke, hypertension, and certain cancers. However, obesity is difficult to control through diet and exercise alone, as they are difficult to implement.
Objective:
The objective of this review is to elucidate the active constituents that can be obtained from various natural sources that act as anti-obesity agents. Due to the global rise in the prevalence of obesity, an urgent need to prevent and control it has arisen.
Methods:
For this review, we compiled information about natural anti-obesity products through an electronic search of the articles available via PubMed, Scopus, and other internet sources for the period 1975-2019 and included our own research. We analyzed and organized data on various natural products in popular use in addition to relevant pharmacognostic and biological studies. The products' mechanisms of action were also investigated.
Conclusion:
Consumption of diets that include high amounts of active anti-obesity natural compounds is a promising strategy for the suppression of lipid accumulation and adipogenesis in obese individuals.
Insights
Natural compounds offer a promising approach to combat obesity, a global health challenge. Dietary intake of these active agents can help reduce fat accumulation and adipogenesis in individuals with obesity.
Area of Science:
- Pharmacognosy and Natural Product Chemistry
- Metabolic Health and Obesity Research
Background:
- Obesity is a global health crisis, significantly increasing the risk of metabolic syndrome, including diabetes, cardiovascular disease, hypertension, and cancer.
- Traditional methods like diet and exercise are often insufficient for effective obesity management due to implementation challenges.
Purpose of the Study:
- To identify and review active constituents from natural sources with anti-obesity properties.
- To address the urgent need for effective obesity prevention and control strategies in light of rising global prevalence.
Main Methods:
- Comprehensive literature search of PubMed, Scopus, and other online databases (1975-2019).
- Inclusion of own research, analysis of popular natural products, and review of pharmacognostic and biological studies.
- Investigation into the mechanisms of action of identified natural anti-obesity agents.
Main Results:
- Identification of various natural compounds with demonstrated anti-obesity effects.
- Analysis of pharmacognostic and biological data supporting the efficacy of these natural products.
- Elucidation of the mechanisms by which these compounds suppress lipid accumulation and adipogenesis.
Conclusions:
- Dietary incorporation of natural compounds with anti-obesity activity presents a viable strategy for managing obesity.
- These natural agents show potential in suppressing lipid accumulation and adipogenesis, offering a promising therapeutic avenue.
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