Lead Anti-Obesity Compounds from Nature
Vinesh Dahiya1, Neeru Vasudeva1, Sunil Sharma1
1Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, India.
Summary
Natural compounds offer a promising approach to combat obesity, a global health challenge. Dietary intake of these active agents can help reduce fat accumulation and adipogenesis in individuals with obesity.
Area of Science:
- Pharmacognosy and Natural Product Chemistry
- Metabolic Health and Obesity Research
Background:
- Obesity is a global health crisis, significantly increasing the risk of metabolic syndrome, including diabetes, cardiovascular disease, hypertension, and cancer.
- Traditional methods like diet and exercise are often insufficient for effective obesity management due to implementation challenges.
Purpose of the Study:
- To identify and review active constituents from natural sources with anti-obesity properties.
- To address the urgent need for effective obesity prevention and control strategies in light of rising global prevalence.
Main Methods:
- Comprehensive literature search of PubMed, Scopus, and other online databases (1975-2019).
- Inclusion of own research, analysis of popular natural products, and review of pharmacognostic and biological studies.
- Investigation into the mechanisms of action of identified natural anti-obesity agents.
Main Results:
- Identification of various natural compounds with demonstrated anti-obesity effects.
- Analysis of pharmacognostic and biological data supporting the efficacy of these natural products.
- Elucidation of the mechanisms by which these compounds suppress lipid accumulation and adipogenesis.
Conclusions:
- Dietary incorporation of natural compounds with anti-obesity activity presents a viable strategy for managing obesity.
- These natural agents show potential in suppressing lipid accumulation and adipogenesis, offering a promising therapeutic avenue.
Keywords:
Obesityanti-lipolytic compoundsanti-obesity compoundsmarine
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