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The Contribution of Additional Sampling in Cholecystectomy Materials: A Multicenter Prospective Study
Samir Abdullazade1, Fahire Göknur Akarca, Güldal Esendagli
1Department of Pathology, İzmir Tepecik Education and Research Hospital, İZMİR, TURKEY.
Turk Patoloji Dergisi
|May 5, 2020
Summary
Additional sampling of cholecystectomy specimens significantly aids diagnosis. Standardized criteria for macroscopic and microscopic examination are crucial for accurate gallbladder lesion diagnosis.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Histopathology
Background:
- Cholecystectomy is a common surgical procedure.
- Gallbladder lesions are frequently encountered in routine pathology practice.
- Diagnostic consistency and reporting standardization are critical for accurate patient management.
Purpose of the Study:
- To determine the frequency of gallbladder lesions.
- To assess diagnostic consistency in cholecystectomy specimens.
- To evaluate the impact of standardized macroscopic and microscopic examination criteria.
Main Methods:
- A multicenter study involving 14 institutions.
- Analysis of 5,244 routinely examined cholecystectomy specimens.
- Inclusion of additional sampling based on defined criteria to assess diagnostic yield.
Main Results:
- Additional sampling was required in 10.98% (576 cases) of specimens.
- The number of additional samples and blocks significantly increased (mean 8 samples, 4 blocks).
- Additional sampling led to a change in diagnosis in 144 cases.
Conclusions:
- Additional sampling of cholecystectomy specimens can improve diagnostic accuracy.
- Standardized criteria for macroscopic and microscopic evaluation are essential for reliable diagnoses.
- This study highlights the importance of rigorous pathological examination of gallbladder specimens.
