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Updated: Dec 22, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
Association between chest CT features and clinical course of Coronavirus Disease 2019
Zhibing Luo1, Na Wang1, Ping Liu2
1Respiratory and Critical Care Center, Shanghai East Hospital Affiliated by Tongji University, China.
Insights
Radiographic characteristics of Coronavirus Disease (COVID-19) imaging can aid in early recognition. Comprehensive assessment of imaging and lab results provides a clearer understanding of COVID-19 progression.
Area of Science:
- Radiology
- Infectious Diseases
- Pulmonology
Background:
- Coronavirus Disease (COVID-19) is a significant global health concern.
- Understanding its radiographic manifestations is crucial for diagnosis and management.
Purpose of the Study:
- To illustrate the radiographic characteristics of COVID-19.
- To correlate imaging findings with the clinical course of the disease.
Main Methods:
- Retrospective study of 195 hospitalized COVID-19 patients.
- Analysis of chest computed tomography (CT) scans, clinical data, and laboratory results.
- Evaluation of radiographic evolution and outcomes over time.
Main Results:
- Common findings include bilateral, peripheral, multi-lobar ground-glass opacities and consolidation.
- Younger patients were more likely to have stable or improving conditions.
- Positive imaging findings correlated with older age and specific laboratory abnormalities (elevated CRP, LDH; decreased lymphocytes, albumin).
Conclusions:
- Specific imaging changes during disease progression can assist in early COVID-19 recognition and differential diagnosis.
- Integrating imaging features with laboratory results offers a comprehensive understanding of COVID-19.
Purpose:
This retrospective study aims to illustrate the radiographic characteristics of Coronavirus Disease 2019 and the correlation with the clinical course.
Methods:
195 hospitalized patients confirmed as Coronavirus Disease 2019 at First Hospital of Changsha, Hunan Province from December 31, 2019 to February 20, 2020 were enrolled. Chest computed tomography scan, clinical data and laboratory tests results were collected accordingly. Variable characteristics were recorded, radiographic evolution and outcome were analyzed along with the time course. Representative laboratory tests results were analyzed based on the image findings.
Results:
Majority of the patients showed bilateral (73.8%), multiple lobes involvements (75.9%), peripheral distribution (83.1%), ground-glass opacification (41.0%), increased vascular margins (63.1%), long axis parallelism (55.9%), patchy ground-glass opacities beneath the pleura (51.3%) and consolidation (45.6%). According to the repeated radiology analysis, patients of improving/stable group tended to have younger age compared with worsening group (45.3 ± 15.0 VS. 59.3 ± 13.5, P = 0.001). Based on the laboratory test results, patients with positive image findings shared elder age, 46.0 (35.0-60.0)VS.31.0 (12.0-37.0) P < 0.001, and higher chance developing fever(P < 0.05); higher level of lymphocytes, C-reactive protein, erythrocyte sedimentation rate and lactate dehydrogenase; lower level of white blood cells, neutrophil and albumin(P < 0.001).
Conclusions:
There are several specific image changes along with the disease progression may be helpful in early recognition and differential diagnosis of Coronavirus Disease 2019. Comprehensive assessments of both imaging feature and laboratory test results may offer an intact knowledge of Coronavirus Disease 2019.
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