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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Combining endocannabinoids with retigabine for enhanced M-channel effect and improved KV7 subtype selectivity

Johan E Larsson1, Urban Karlsson1, Xiongyu Wu2

  • 1Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

The Journal of General Physiology
|May 5, 2020
PubMed
Summary

Arachidonoyl-L-serine (ARA-S), a novel endocannabinoid, activates neuronal M-channels. Combining ARA-S with retigabine enhances M-channel activation while improving KV7 subtype selectivity, potentially reducing side effects.

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