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Efficacy and safety of dupilumab in atopic dermatitis in elderly patients: a retrospective study

M Napolitano1, G Fabbrocini2, M Scalvenzi2

  • 1Department of Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy.

Clinical and Experimental Dermatology
|May 5, 2020
PubMed

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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