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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

Salivary Gland Dysfunction, Protein Glycooxidation and Nitrosative Stress in Children with Chronic Kidney Disease

Mateusz Maciejczyk1, Julita Szulimowska2, Katarzyna Taranta-Janusz3

  • 1Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 2c Mickiewicza Street, 15-233 Bialystok, Poland.

Journal of Clinical Medicine
|May 6, 2020
PubMed

Insights

Children with chronic kidney disease (CKD) experience salivary gland dysfunction, leading to increased oxidative and nitrosative stress in saliva. This dysfunction worsens with CKD progression.

Area of Science:

  • Biochemistry
  • Nephrology
  • Oral Medicine

Background:

  • Chronic kidney disease (CKD) can affect salivary gland function.
  • Oxidative stress markers are increasingly recognized in various systemic diseases.

Purpose of the Study:

  • To investigate protein glycooxidation, lipid oxidative damage, and nitrosative stress in the saliva of children with CKD.
  • To compare these markers in children with normal salivary secretion versus hyposalivation (reduced saliva flow).

Main Methods:

  • Analysis of non-stimulated (NWS) and stimulated whole saliva (SWS) in children with CKD (stages 1-5) and healthy controls.
  • Subgrouping CKD patients based on salivary flow rate (normal vs. hyposalivation).
  • Measurement of salivary amylase activity, total protein, glycooxidation products, lipid peroxidation markers, and nitrosative stress markers.

Main Results:

  • Hyposalivation was prevalent in advanced CKD (stage 4-5).
  • CKD children with hyposalivation showed significantly lower salivary amylase and total protein.
  • Elevated levels of protein glycooxidation, lipid oxidation, and nitrosative stress markers were found in the saliva and plasma of CKD children with hyposalivation.
  • Salivary oxidation markers correlated negatively with salivary flow rate, amylase activity, and protein content but did not reflect plasma levels.

Conclusions:

  • Children with CKD exhibit salivary gland dysfunction.
  • Salivary oxidative and nitrosative stress increases with CKD severity and impaired salivary function.
  • Salivary gland dysfunction is a significant complication in pediatric CKD.

Keywords:
chronic kidney diseasenitrosative stressoxidative stresssalivary biomarkerssalivary gland dysfunction

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