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Related Experiment Videos

Deacclimation period in ventricular function after high altitude expedition.

S Mori1, S Watanabe, K Shimaoka

  • 1Department of Aerospace Physiology, Nagoya University, Japan.

The Japanese Journal of Physiology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Cardiac function in mountaineers shows lasting changes for up to a year after high-altitude exposure. Ventricular-ejection time/heart-rate ratio and ejection time index reveal persistent effects of hypoxic acclimation.

Area of Science:

  • Physiology
  • Altitude Medicine
  • Cardiovascular Research

Background:

  • High altitude exposure significantly impacts cardiovascular function.
  • The duration of residual effects from hypoxic acclimation on cardiac parameters is not well understood.

Purpose of the Study:

  • To investigate the long-term effects of high-altitude exposure on cardiac function.
  • To determine if cardiac adaptations to hypoxia persist for at least one year post-exposure.

Main Methods:

  • Impedance cardiography was used to measure ventricular-ejection time/heart-rate ratio (VET/HR) and ejection time index (ETI).
  • Measurements were taken in a decompression chamber simulating hypoxic conditions.
  • Subjects included mountaineers with recent high-altitude experience (>6,000 m) and a control group.

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Main Results:

  • Mountaineers with recent high-altitude exposure exhibited more labile VET/HR and ETI values during hypoxic exposure.
  • Initially, these subjects showed significantly higher ETI values compared to the non-experienced group.
  • ETI values in the experienced group approached those of the non-experienced group in later hypoxic exposures.

Conclusions:

  • Hypoxic acclimation appears to have a lasting effect on cardiac function, potentially persisting for at least one year after returning to sea level.
  • Cardiac function, specifically ETI, may remain altered in individuals with prior high-altitude exposure, indicating sustained physiological adaptation.