Related Experiment Video
Updated: Dec 22, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
The Role of Wnt Signalling in Chronic Kidney Disease (CKD)
Soniya A Malik1, Kavindiya Modarage1, Paraskevi Goggolidou1
1Department of Biomedical Science and Physiology, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UK.
Abstract:
Chronic kidney disease (CKD) encompasses a group of diverse diseases that are associated with accumulating kidney damage and a decline in glomerular filtration rate (GFR). These conditions can be of an acquired or genetic nature and, in many cases, interactions between genetics and the environment also play a role in disease manifestation and severity. In this review, we focus on genetically inherited chronic kidney diseases and dissect the links between canonical and non-canonical Wnt signalling, and this umbrella of conditions that result in kidney damage. Most of the current evidence on the role of Wnt signalling in CKD is gathered from studies in polycystic kidney disease (PKD) and nephronophthisis (NPHP) and reveals the involvement of beta-catenin. Nevertheless, recent findings have also linked planar cell polarity (PCP) signalling to CKD, with further studies being required to fully understand the links and molecular mechanisms.
More Related Videos
Related Concept Videos
Chronic Kidney Disease I: Introduction
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathways
Chronic Kidney Disease III: Interprofessional Care
Nephrons
Chronic Kidney Disease II: Clinical Manifestations

