Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

3.7K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
3.7K
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

744
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
744
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

139
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
139
ER Retrieval Pathway01:45

ER Retrieval Pathway

4.5K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
4.5K
Regulated Protein Degradation02:58

Regulated Protein Degradation

2.9K
2.9K
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

171
Body:Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
171

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Role of point-by-point light sensitivity in the assessment of glaucoma progression].

Vestnik oftalmologii·2024
Same author

[Minoxidil-induced ophthalmic hypertension (case report)].

Vestnik oftalmologii·2024
Same author

[The effect of keratoconus-associated refractive errors on the results of tomographic methods of studying the posterior structures of the eye].

Vestnik oftalmologii·2023
Same author

[Static automated perimetry in the diagnosis of glaucoma. Assessment of disease progression].

Vestnik oftalmologii·2023
Same author

[Modern achievements in the diagnosis and treatment of glaucoma].

Vestnik oftalmologii·2023
Same author

[Comparative evaluation of hypotensive effectiveness of topical monotherapy and selective laser trabeculectomy].

Vestnik oftalmologii·2022

Related Experiment Video

Updated: Dec 22, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.3K

[Peptide bioregulators: delivery and efficacy].

V P Erichev1, Dzh N Lovpache2, T V Yaremenko3

  • 1Research Institute of Eye Diseases, Moscow, Russia.

Vestnik Oftalmologii
|May 6, 2020
PubMed
Summary

Retinalamin administration, whether intramuscular, retrobulbar, or combined, shows comparable efficacy in treating open-angle glaucoma. The treatment is most effective for initial and moderate stages of the disease.

Keywords:
glaucomaneuroprotectionretinalamin

More Related Videos

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants
08:48

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

11.0K
Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
07:53

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

18.4K

Related Experiment Videos

Last Updated: Dec 22, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
08:48

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

12.3K
Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants
08:48

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

11.0K
Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
07:53

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

18.4K

Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Open-angle glaucoma is a progressive optic neuropathy.
  • Compensated intraocular pressure is crucial for managing glaucoma.
  • Neuroprotection is a key strategy in glaucoma treatment.

Purpose of the Study:

  • To compare the neuroprotective effects of retinalamin administered via different routes in open-angle glaucoma patients.
  • To evaluate the efficacy of intramuscular, retrobulbar, and combined retinalamin administration.

Main Methods:

  • A study involving 498 patients with varying stages of open-angle glaucoma.
  • Patients were divided into three groups receiving different retinalamin administration protocols (intramuscular, retrobulbar, combined).
  • Evaluations included tonometry, static perimetry, and contrast sensitivity tests at baseline, 3 months, and 6 months.

Main Results:

  • Retinalamin administration led to increased total threshold retinal sensitivity, particularly in initial and moderate glaucoma stages.
  • Combined intramuscular and retrobulbar administration showed positive trends up to 6 months.
  • Retrobulbar and intramuscular injections showed varying effects across different glaucoma stages, with some regression observed by month 6.

Conclusions:

  • Retinalamin demonstrates significant neuroprotective effects in open-angle glaucoma, especially in initial and moderate stages.
  • Intramuscular, retrobulbar, and combined administration methods exhibit comparable efficacy.
  • Further research may explore optimal administration protocols for advanced glaucoma stages.