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Related Experiment Video

Updated: Dec 22, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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[Drug-induced glaucoma].

O D Ostroumova1,2, E V Shikh1, E V Rebrova1

  • 1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Vestnik Oftalmologii
|May 6, 2020
PubMed
Summary

Drug-induced glaucoma (DIG) involves elevated intraocular pressure (IOP) and vision loss from medications. Awareness and drug review are key for preventing, detecting, and treating this condition.

Keywords:
adverse reactionsangle-closure glaucomadrug-induced glaucomaglaucomaintraocular pressureopen-angle glaucoma

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Glaucoma is a group of diseases causing optic neuropathy and visual field loss.
  • Elevated intraocular pressure (IOP) is a primary risk factor for glaucoma development.
  • Drug-induced glaucoma (DIG) is characterized by elevated IOP, optic neuropathy, and visual field defects linked to specific medications.

Purpose of the Study:

  • To highlight the significance of drug-induced glaucoma (DIG) as an adverse drug reaction.
  • To inform medical practitioners about various drug classes causing DIG through different mechanisms.
  • To emphasize the importance of awareness for preventing, detecting, and managing DIG.

Main Methods:

  • Review of literature on drug-induced glaucoma.
  • Categorization of drugs causing open-angle and angle-closure glaucoma.
  • Analysis of mechanisms by which drugs elevate IOP.

Main Results:

  • Corticosteroids are a common cause of DIG via the open-angle mechanism.
  • Various drug classes, including NSAIDs and certain antibody therapies, can induce DIG.
  • Anticholinergics, sympathomimetics, antidepressants, and sulfa drugs can cause DIG through angle-closure mechanisms.

Conclusions:

  • Medical practitioners must be aware of DIG to prevent, detect, and manage it effectively.
  • Discontinuing the causative drug often normalizes IOP in DIG.
  • If IOP remains elevated or steroid use is necessary, topical glaucoma medications may be required.