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Updated: Dec 22, 2025
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Evaluating Changes in Immune Function and Bone Microenvironment During Radium-223 Treatment of Patients with
Tanya B Dorff1, Cy Stein1, Marcin Kortylewski2
1Department of Medical Oncology and Developmental Therapeutics, City of Hope National Medical Center, Duarte, California, USA.
Abstract:
The effects of radium-223 on the immune system and the bone tumor microenvironment are incompletely understood. The authors describe mechanisms by which radium-223 may interact with the immune system, specifically through STAT-3 and impact on tumor and circulating lymphocyte populations. They review mechanisms through which effects of radium-223 and androgen-targeted therapy on bone microenvironment could be better elucidated. These knowledge gaps currently limit development of optimal combination therapy approaches for radium-223. Tissue based studies are currently underway in a prospective clinical trial to enhance therapeutic perspective on radium-223 treatment in the prostate cancer landscape.
