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A Rat Model of Oral Mucositis Induced by Cancer Chemotherapy for Quantitative Experiments
Issei Takeuchi1,2, Riko Kawamata1, Kimiko Makino3,2
1Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Background/Aim:
Oral mucositis, which occurs frequently in the treatment of cancer, is a major problem. In this study, we aimed to develop a rat model of oral mucositis induced by cancer chemotherapy for quantitative measurement.
Materials And Methods:
A model animal of oral mucositis was prepared by injecting an acetic acid aqueous solution into the buccal mucosa of rats to which a 5-FU solution had been previously administered. The doses of 5-FU and acetic acid were examined, and a treatment experiment using Kenalog® was performed.
Results:
The optimal dose of the 5-FU solution and the optimal concentration of the acetic acid aqueous solution were 40 mg/kg and 25%, respectively. Treatment with Kenalog® confirmed that this model mimics immunocompromised oral mucositis.
Conclusion:
Compared with a mouse model, oral mucositis can be easily observed in this model and provides a large amount of oral mucosal tissue.