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Updated: Dec 22, 2025

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
Published on: July 18, 2016
Neoadjuvant Chemotherapy Reduces the Treatment-free Interval After First-line Treatment in Patients With Advanced
Anne Weng Ekmann-Gade1, Claus Kim Hogdall2, Svend Aage Engelholm3
1Department of Gynecology, The Juliane Marie Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark anne.weng.ekmann-gade@regionh.dk.
Background/Aim:
The aim of the study was to compare platinum resistance and treatment-free interval (TFI) following treatment with neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) or primary debulking surgery (PDS) in women with advanced epithelial ovarian cancer (EOC).
Patients And Methods:
The study included patients diagnosed with primary EOC, stage IIIC or IV, between 2005 and 2013. Patients were grouped according to first-line treatment (PDS vs. NACT-IDS). Date of second-line treatment initiation was used to evaluate platinum sensitivity.
Results:
The study population included 521 patients, of which 371 (71%) and 150 (29%) underwent PDS and NACT-IDS, respectively. We found no difference in platinum resistance between groups. Platinum-sensitive patients treated with NACT-IDS had a shorter median TFI (372 vs. 497 days, p=0.042). Similarly, patients with no residual tumor after IDS had a shorter median TFI (280 vs. 302 days, p=0.005).
Conclusion:
NACT-IDS may shorten the TFI after first-line platinum-based chemotherapy.
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