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SF3B4 Plays an Oncogenic Role in Esophageal Squamous Cell Carcinoma

Shinya Kidogami1,2, Tomohiro Iguchi1, Kuniaki Sato1

  • 1Department of Surgery, Kyushu University Beppu Hospital, Oita, Japan.

Anticancer Research
|May 6, 2020
PubMed
Abstract

Insights

High Splicing Factor 3b Subunit 4 (SF3B4) expression in esophageal squamous cell carcinoma (ESCC) correlates with lymphatic invasion and poor prognosis. SF3B4 may drive ESCC lymphatic progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The spliceosome pathway, including Splicing Factor 3b Subunit 4 (SF3B4), is implicated in various cancers.
  • The role of SF3B4 in esophageal squamous cell carcinoma (ESCC) has not been previously established.

Purpose of the Study:

  • To investigate the clinical relevance and potential mechanisms of SF3B4 in ESCC.
  • To determine the correlation between SF3B4 expression and clinicopathological features, prognosis, and molecular pathways in ESCC.

Main Methods:

  • SF3B4 expression was quantified using real-time reverse transcription polymerase chain reaction in 80 ESCC patients.
  • SF3B4 mRNA expression and DNA copy number data were analyzed from The Cancer Genome Atlas (TCGA).
  • Gene Set Enrichment Analysis (GSEA) was performed to explore associated molecular pathways.

Main Results:

  • Higher SF3B4 expression was significantly associated with increased lymphatic permeation and poorer patient prognosis.
  • GSEA indicated that high SF3B4 expression correlates with E2F transcription factor targets and the G2/M cell cycle checkpoint.
  • SF3B4 expression levels showed a positive correlation with SF3B4 DNA copy number.

Conclusions:

  • Overexpression of SF3B4 is a potential driver of lymphatic progression in ESCC.
  • SF3B4 may represent a novel therapeutic target for managing ESCC progression and improving patient outcomes.
Keywords:
SF3B4esophageal squamous cell carcinomapoor prognostic biomarker

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