Developmental trajectories of infants born at less than 30 weeks' gestation on the Bayley-III Scales

Chloe Durrant1, Hilary S Wong2, Tim J Cole3

  • 1Cognitive Neuroscience and Neuropsychiatry Programme, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Insights

The rate of development, not a single assessment, best predicts developmental trajectories in very preterm infants. Lower gestational age, birth weight, and male sex are linked to slower development rates.

Area of Science:

  • Neonatal Development
  • Developmental Pediatrics
  • Perinatal Medicine

Background:

  • Very preterm infants (<30 weeks' gestation) exhibit diverse developmental trajectories.
  • Early identification of developmental risks is crucial for timely intervention.
  • Standardized assessments like the Bayley Scales of Infant and Toddler Development (Bayley-III) are used to track development.

Purpose of the Study:

  • To characterize cognitive, language, and motor developmental trajectories in very preterm infants.
  • To identify perinatal factors influencing these developmental trajectories.

Main Methods:

  • Utilized data from 1142 infants born <30 weeks' gestation.
  • Applied Super Imposition by Translation and Rotation (SITAR) growth curve analysis to Bayley-III scores at 3, 6, 12, and 24 months corrected age.
  • Modeled cognitive, receptive/expressive language, and fine/gross motor development.

Main Results:

  • SITAR models successfully explained significant variance in cognitive (62%), receptive communication (68%), fine motor (53%), and gross motor (68%) development.
  • The rate of development (curve gradient) was the primary predictor of developmental trajectories across domains.
  • Lower gestational age, lower birth weight, and male sex were associated with slower developmental rates.

Conclusions:

  • The rate of development is a more robust predictor of very preterm infant trajectories than single time-point assessments.
  • Monitoring developmental rate is essential for early intervention strategies in this population.
Abstract

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