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Published on: December 8, 2020
Optical measurement platform of temperature-dependent interaction between nanoliposomes and a polymer-grafted surface
Virendra Majarikar1, Hiroaki Takehara2,3, Takanori Ichiki4,5
1Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Abstract:
In this study, we report an opto-microfluidic platform integrated with dark-field light scattering imaging and fluorescence microspectroscopy to investigate the temperature-dependent behavior of nanoliposomes. This newly developed experimental platform enabled both in situ measurements of the temperature of the sample solution and observation of individual nanoliposomes. As a proof-of-concept, the temperature-dependent interaction between 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC) nanoliposomes and a poly(ethylene glycol) (PEG) grafted surface was investigated using this opto-microfluidic platform. Temperature-dependent detachment behavior of DLPC nanoliposomes, which was because of the phase transition of DLPC, was observed. The opto-microfluidic platform for individual nanoparticle measurements may become a powerful tool for investigating temperature-dependent physicochemical properties of nanoparticles in aqueous solution.
