Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of oseltamivir-resistant A(H5N1) clade 2.3.4.4b, genotype D1.1 variants identified in poultry farms of British Columbia, Canada.

Emerging microbes & infections·2026
Same author

A VSV-vector vaccine simultaneously targeting H5N1 hemagglutinin and matrix protein 2 induces robust neutralizing and ADCC antibody responses and provides full protection against lethal H5N1 infection in a mouse model.

Journal of virology·2026
Same author

Early Surge in Brain GFAP Distribution in Female Hamsters With Mild Peripheral COVID-19.

Journal of neurochemistry·2026
Same author

Waning humoral immunity following monkeypox virus infection and vaccination, Canada, 2020 to 2023.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2026
Same author

Mammary and respiratory infection of sheep with H5Nx clade 2.3.4.4b viruses with milk-mediated transmission to lambs.

Science advances·2026
Same author

Searching for immune correlates in Lassa vaccine development - workshop report.

NPJ vaccines·2026

Related Experiment Video

Updated: Dec 22, 2025

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice
10:01

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Published on: October 17, 2018

8.4K

Evaluating Zika Virus Pathogenesis in Immunocompromised Mice.

Bryan D Griffin1, David Safronetz1,2, Darwyn Kobasa3,4

  • 1Zoonotic Diseases and Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada.

Methods in Molecular Biology (Clifton, N.J.)
|May 6, 2020
PubMed
Summary

Mouse models are crucial for understanding Zika virus (ZIKV) pathogenesis and testing ZIKV treatments. This chapter details available models and evaluates pathogenesis in an immunocompromised mouse model.

Keywords:
Animal modelFlavivirusInterferonMousePathogenesisZika virus

More Related Videos

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse
10:31

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse

Published on: August 15, 2019

7.9K
Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
09:39

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

9.0K

Related Experiment Videos

Last Updated: Dec 22, 2025

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice
10:01

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Published on: October 17, 2018

8.4K
Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse
10:31

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse

Published on: August 15, 2019

7.9K
Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
09:39

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult

Published on: April 26, 2018

9.0K

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Zika virus (ZIKV) infection poses significant public health challenges.
  • Mouse models are essential for studying ZIKV pathogenesis and evaluating potential interventions.
  • Existing models recapitulate some, but not all, aspects of human ZIKV infection.

Purpose of the Study:

  • To review available mouse models for ZIKV infection research.
  • To describe the evaluation of ZIKV pathogenesis in immunocompromised mice.
  • To highlight the utility of mouse models for antiviral and vaccine screening.

Main Methods:

  • Review of literature on established ZIKV mouse models.
  • Pathogenesis evaluation in a specific immunocompromised mouse model.
  • Assessment of ZIKV replication and host response.

Main Results:

  • Mouse models effectively mimic certain ZIKV infection characteristics.
  • Immunocompromised models offer unique insights into ZIKV pathogenesis.
  • These models are vital for preclinical assessment of ZIKV countermeasures.

Conclusions:

  • Available mouse models are indispensable tools for ZIKV research.
  • Further characterization of ZIKV pathogenesis in various models is warranted.
  • Mouse models facilitate the development of effective ZIKV therapeutics and vaccines.