Circular RNA HIPK3 is a Prognostic and Clinicopathological Predictor in Malignant Tumor Patients

Objectives: Circular RNA Homeodomain Interacting Protein Kinase 3 (circHIPK3) is one of the most researched circRNAs in recent 5 years. Many individual studies confirmed that aberrantly expression of circHIPK3 held prognostic value in various tumors. Thus, the aim of this meta-analysis is to assess its prognostic potentials and functions in malignant tumors. Materials and methods: Multiple databases were carefully searched for articles published about circHIPK3 over the past 10 years. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to demonstrate prognostic value of circHIPK3 using Stata 15.0 software. Results: 8 studies including 1175 patients were ultimately enrolled in this meta-analysis. Pooled results showed that abnormal expression of circHIPK3 was significantly correlated with unfavorable OS (pooled HR=2.12, 95% CI: 1.69-2.66) and DFS/PFS (HR=2.28, 95% CI: 1.67-3.10) in cancer patients. Additionally, abnormal expression of circHIPK3 was also related to the distal metastasis of the tumors (OR: 3.27, 95%CI: 2.16-4.97, p<0.001). Conclusions: Abnormal expression of circHIPK3, no matter high or low expression, was associated with poor clinical outcomes in multiple cancer types. More comprehensive studies were required to verify and strengthen the clinical value of circHIPK3 in human malignant diseases.