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Non-traumatic and non-drug-induced rhabdomyolysis

Genovefa Kolovou1, Philip Cokkinos1, Helen Bilianou2

  • 1Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.

Archives of Medical Sciences. Atherosclerotic Diseases
|May 6, 2020
PubMed

Insights

Rhabdomyolysis (RM) is a rare muscle cell disease that can result from various non-traumatic conditions. This review covers the pathology, clinical signs, and management of non-drug-induced RM.

Area of Science:

  • Medicine
  • Pathology
  • Biochemistry

Background:

  • Rhabdomyolysis (RM) is a rare disease affecting striated muscle cells.
  • It can arise from traumatic or non-traumatic causes, including congenital and acquired conditions.
  • Specific circumstances like toxic substance use and certain medications (e.g., lipid-lowering drugs) can also trigger RM.

Purpose of the Study:

  • To provide a comprehensive review of non-traumatic and non-drug-induced Rhabdomyolysis.
  • To discuss the underlying pathology, clinical manifestations, and biochemical effects of RM.
  • To outline the recommended management strategies for Rhabdomyolysis.

Main Methods:

  • Literature review of scientific articles and clinical studies.
  • Analysis of pathological mechanisms and clinical presentations of Rhabdomyolysis.
  • Synthesis of information on diagnosis and therapeutic interventions.

Main Results:

  • Non-traumatic RM encompasses a range of congenital and acquired conditions.
  • Clinical and biochemical findings vary depending on the underlying cause.
  • Effective management involves addressing the primary cause and supportive care.

Conclusions:

  • Non-traumatic, non-drug-induced Rhabdomyolysis requires thorough investigation to identify the underlying cause.
  • Understanding the pathology and clinical features is crucial for timely diagnosis and treatment.
  • Prompt and appropriate management can mitigate complications and improve patient outcomes.
Keywords:
dystrophymyoglobulinmyopathyrhabdomyolysis

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