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Related Experiment Videos

Edema resulting from experimental filariasis.

D S Folse1, A Ewert

  • 1Department of Pathology, University of Texas Medical Branch, Galveston.

Lymphology
|December 1, 1988
PubMed
Summary

Domestic cats and patas monkeys infected with Brugia malayi showed localized lymphatic filariasis. While cats developed visible edema, monkeys exhibited disrupted lymph flow, detectable via lymphscintigraphy.

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Area of Science:

  • Veterinary Medicine
  • Parasitology
  • Immunology

Background:

  • Brugia malayi is a filarial parasite causing lymphatic filariasis.
  • Understanding host-parasite interactions is crucial for disease management.

Purpose of the Study:

  • To investigate the pathological effects of Brugia malayi infection in domestic cats and patas monkeys.
  • To compare the clinical and physiological responses to filarial infection in these two species.

Main Methods:

  • Infection of cats and monkeys with Brugia malayi, with worms localizing in hind leg lymphatics.
  • Gross, light, and electron microscopy of edematous tissues.
  • Assessment of lymph flow using dye injection, X-ray contrast media, and lymphscintigraphy.

Main Results:

  • Cats developed clinical edema, while monkeys did not show visible swelling.
  • Disruption of normal lymph flow was evident in monkeys, confirmed by lymphscintigraphy.
  • Filarial parasites localized in the regional lymphatics of the hind legs in both species.

Conclusions:

  • Brugia malayi infection elicits different clinical manifestations in cats and monkeys.
  • Lymphscintigraphy is a valuable tool for detecting subclinical lymphatic dysfunction in filarial infections.

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