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Preeclampsia was a risk factor for pulmonary interstitial emphysema in preterm infants born ≤32 weeks of gestational

Judith Behnke1,2, Anita Windhorst3, Frank Oehmke4

  • 1Department of General Pediatrics & Neonatology, Justus Liebig University and Universities of Giessen and Marburg Lung Center, Giessen, Germany.

Acta Paediatrica (Oslo, Norway : 1992)
|May 6, 2020
PubMed

Insights

Preeclampsia and HELLP syndrome are new risk factors for pulmonary interstitial emphysema (PIE) in preterm infants. Early identification of these conditions can help predict infants at risk for PIE and severe complications.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Perinatal Research

Background:

  • Pulmonary interstitial emphysema (PIE) is a serious complication in preterm infants.
  • Identifying prenatal and postnatal risk factors for PIE is crucial for improving outcomes.

Purpose of the Study:

  • To determine prenatal and postnatal risk factors for PIE in preterm infants.
  • To assess the contribution of these risk factors to severe complications.

Main Methods:

  • Retrospective analysis of 179 preterm infants (up to 32 weeks gestational age).
  • Chest X-rays analyzed within the first five days of life.
  • Univariate analyses and multivariable logistic regression used to identify risk factors.

Main Results:

  • Confirmed known risk factors: gestational age and birthweight.
  • Identified preeclampsia and HELLP syndrome as additional risk factors for PIE (P=.027).
  • Associated PIE with respiratory distress syndrome, increased oxygen requirements, and surfactant use.

Conclusions:

  • Preeclampsia and HELLP syndrome are potential additional risk factors for PIE in preterm infants.
  • Inclusion of these conditions in future studies can aid early identification of at-risk infants.
Abstract

Keywords:
air leakmechanical ventilationpreeclampsiaprematuritypulmonary interstitial emphysema

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