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Development or Disease: Caspases Balance Growth and Immunity in C. elegans
Olya Yarychkivska1, Shai Shaham1
1Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Developmental Cell
|May 6, 2020
Abstract:
Caspase proteases execute apoptosis but also function in development. In this issue of Developmental Cell, Weaver et al. report that C. elegans CED-3 caspase promotes animal growth through PMK-1/p38 kinase cleavage, and at the expense of pathogen and stress immunity, revealing an unexpected homeostatic relationship between development and disease.
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