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Considerations for pharmacoepidemiological analyses in the SARS-CoV-2 pandemic
Anton Pottegård1, Xavier Kurz2, Nicholas Moore3
1Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Pharmacoepidemiology and Drug Safety
|May 6, 2020
Summary
This paper outlines methodological considerations for conducting pharmacoepidemiologic studies during the COVID-19 pandemic. It emphasizes timely, valid evidence generation for drug safety and effectiveness research.
Area of Science:
- Epidemiology
- Pharmacology
- Public Health
Background:
- The COVID-19 pandemic necessitated rapid generation of evidence on medication use, infection risk, and prognosis.
- Existing research methodologies required adaptation to address urgent public health questions during the pandemic.
Purpose of the Study:
- To provide methodological guidance for designing and conducting robust pharmacoepidemiologic studies during the COVID-19 pandemic.
- To address key considerations for generating reliable evidence on medication use in the context of a global health crisis.
Main Methods:
- The paper reviews eight critical domains for pharmacoepidemiologic study conduct.
- Key areas include timeliness, alignment of research types, real-time data challenges, study design, exposure and covariate definition, outcome assessment, and transparent reporting.
Main Results:
- Methodological considerations are presented across eight domains crucial for pandemic-related pharmacoepidemiology.
- Guidance is offered on prioritizing research questions, integrating observational and interventional studies, and defining study parameters.
Conclusions:
- Adherence to rigorous methodological standards is essential for producing valid and reliable pharmacoepidemiologic evidence during public health emergencies.
- This guidance supports the scientific community in conducting impactful research during the COVID-19 pandemic and future health crises.
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