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At the heart of COVID-19

Inayat Hussain Khan1, Syeda Anum Zahra1, Sevim Zaim2

  • 1Department of Medicine, St George's Hospital Medical School, London, UK.

Journal of Cardiac Surgery
|May 6, 2020
PubMed

Insights

Coronavirus disease (COVID-19) impacts the cardiovascular system, especially in older adults and those with comorbidities. Research is ongoing into COVID-19

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Coronavirus disease (COVID-19) emerged in late 2019 and rapidly became a global pandemic.
  • While COVID-19 affects all demographics, older individuals and those with comorbidities face higher risks of severe disease and adverse outcomes.
  • Pre-existing cardiovascular disease (CVD) may increase vulnerability to COVID-19, though its prevalence in affected patients is under-reported.

Purpose of the Study:

  • To review recent advancements in understanding the complex interplay between COVID-19 and the cardiovascular system.
  • To explore the potential direct and indirect mechanisms through which COVID-19 affects cardiovascular health.
  • To highlight the role of angiotensin-converting enzyme 2 (ACE2) in both cardiovascular disease and COVID-19 pathogenesis.

Main Methods:

  • This is a review article, synthesizing current scientific literature.
  • The review focuses on recent research concerning COVID-19's cardiovascular implications.
  • Key areas examined include pathogenic mechanisms and potential therapeutic targets.

Main Results:

  • COVID-19 can directly and indirectly impact the cardiovascular system, although precise mechanisms require further elucidation.
  • Angiotensin-converting enzyme 2 (ACE2) is implicated in the pathogenesis of COVID-19 and has known cardiovascular effects.
  • Research is actively exploring antiviral treatments and vaccines for COVID-19.

Conclusions:

  • Understanding the cardiovascular effects of COVID-19 is crucial for managing patients during the pandemic.
  • Further research is needed to clarify the specific pathways of cardiovascular involvement and to develop targeted therapies.
  • The ongoing development of antivirals and vaccines remains a priority in combating COVID-19.

Keywords:
COVID-19cardiovascularheart

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